乐鱼-欧盟评估可得然胶作为食品添加剂的安全性

欧盟评估可得然胶作为食物添加剂的平安性时候：2024-09-11 16:30来历：食物火伴网作者： 泽夕 焦点提醒：2024年9月9日，据欧盟食物平安局（EFSA）动静，欧盟食物添加剂和调味剂小组（FAF）便可得然胶（curdlan）作为食物添加剂的平安性颁发科学定见。 食物火伴网讯 2024年9月9日，据欧盟食物平安局（EFSA）动静，欧盟食物添加剂和调味剂小组（FAF）便可得然胶（curdlan）作为食物添加剂的平安性颁发科学定见。 颠末评估，专家小组得出结论，在拟议的用处和利用程度下，可得然胶作为食物添加剂不存在平安问题。部门原文报导以下： The EFSA Panel on Food Additives and Flavourings (FAF) provides a scientific opinion on the safety of curdlan as a new food additive used as firming and gelling agent, stabiliser, thickener. Curdlan is a high molecular weight polysaccharide consisting of -1,3-linked glucose units, produced by fermentation from Rhizobium radiobacter biovar 1 strain NTK-u. The toxicological dataset consisted of sub-chronic, chronic and carcinogenicity, reproductive and developmental toxicity studies as well as genotoxicity. In vivo data showed that curdlan is not absorbed as such but is extensively metabolised by the gut microbiota into CO2 and other innocuous compounds. Curdlan was not genotoxic and was well-tolerated with no overt organ-specific toxicity. Effects observed at very high doses of curdlan, such as decreased growth and increased cecum weight, are common for indigestible bulking compounds and therefore considered physiological responses. In a combined three-generation reproductive and developmental toxicity study, decreased pup weight was observed during lactation at 7500 mg curdlan/kg body weight (bw) per day, the highest dose tested. The Panel considered the observed effects as treatment-related and adverse, although likely secondary to nutritional imbalance and identified a conservative no observed adverse effect level (NOAEL) of 2500 mg/kg bw per day. Despite the limitations noted in the dataset, the Panel was able to conclude applying the margin of exposure (MOE) approach. Given that curdlan and its break-down products are not absorbed and that the identified adverse effect is neither systemic nor local, no adjustment factor was deemed necessary. Thus, an MOE of at least 1 was considered sufficient. The highest exposure estimate was 1441 mg/kg bw per day in toddlers at the 95th percentile of the proposed maximum use level exposure assessment scenario. The Panel concluded that there is no safety concern for the use of curdlan as a food additive at the proposed uses and use levels. 本文由食物火伴网食物资讯中间编纂，供网友参考，有任何疑问，请联系news@foodmate.net。